Cancer remains a daunting challenge in modern medicine, affecting millions worldwide. Breast cancer, in particular, is one of the most common cancers diagnosed in women. The search for more effective and less harmful treatments is an ongoing endeavor. Recently, Avenzo Therapeutics, a US-based company, announced the start of an open-label Phase I/II trial for their new drug

Breast cancer remains a significant global health challenge, with numerous subtypes and varying patient responses to treatment. Among these, hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer is the most common, often presenting as locally advanced or metastatic disease. For patients with tumors harboring mutations in the PIK3CA gene, resistance to standard hormone therapy can lead to poorer outcomes.