This research looks at how memory and thinking skills change in middle-aged Spanish people who don't have the brain changes usually seen in Alzheimer's disease. Scientists checked their brain fluid to confirm this. They used special methods to track these changes over time and created new ways to compare their scores that are more sensitive than regular tests. The results suggest these new methods might be slightly better at finding very early, subtle declines in memory, which could be a sign of preclinical Alzheimer's. This study hopes to provide doctors with another tool to help spot early changes that might lead to Alzheimer's later in life.

Explore the Hepatitis B global clinical trial landscape in 2025 with insights into novel therapies, ongoing research for a functional cure, emerging biomarkers, and investment trends from a new report by Novotech

Explore the critical topic of minority engagement in US clinical research on the Glassbury Cares Podcast. We discuss the persistent challenges of lower participation rates among racial and ethnic minorities in clinical trials, including HIV research. Understand how distrust of the medical community and research, significantly influenced by historical events like the Tuskegee study, acts as a barrier. Learn about other impediments, such as accessibility issues, time commitments, language barriers, stigma, and limited knowledge. Discover facilitators that encourage participation, including altruism, perceived personal and community benefits, trust, culturally relevant services, and monetary compensation. We examine ethical considerations, the importance of justice, and strategies like community-based participatory research to build trust and address structural barriers