The Unexpected Guests: How Bacterial Signals Are Hiding Inside Brain Tumors and Reshaping Cancer Research

Malignant brain tumors, including gliomas (like glioblastomas, GBM) and brain metastases (BrM), are among the most difficult cancers to treat, often leading to a challenging prognosis for patients despite the best available therapies—surgery, radiation, and systemic treatments. Researchers are desperately seeking a deeper understanding of the brain tumor microenvironment (TME) to advance biology and improve patient outcomes.