Phase I Clinical Trials: Participant Insights, Systemic Pressures, and Safety-First Protocols
Dive into the complex world of Phase I clinical trials, where healthy volunteers test new drugs for safety in exchange for financial compensation. Discover the unspoken dynamics and perverse incentives that lead participants to strategically manage disclosures and navigate strict exclusion criteria to maintain eligibility and maximize their income. Understand the prevalent "better safe than sorry" atmosphere that shapes this challenging research environment and influences participant behavior.
Dialectical Thinking: A Drain on Your Well-being? Culture & Age Play a Role!
This study investigates the complex relationship between holding dialectical views on contradictions and psychological well-being, specifically examining depressive symptoms and life satisfaction. It explores the moderating roles of culture (European American vs. Asian American) and age, and the mediating role of mindfulness facets. Findings indicate that dialectical views are associated with increased depressive symptoms and lower life satisfaction primarily among younger European Americans,
Why Healthcare Systems Need Redesign
Explore the significant impact of medical errors in healthcare, estimated to cause tens of thousands of deaths annually in the U.S.. Understand how systemic issues and processes contribute to preventable harm. Learn why system redesign, informed by human factors and systems engineering, is crucial for avoiding injuries to patients and improving safety.
Understanding Dementia Risk for Veterans Diagnosed with PTSD
PTSD is highly prevalent among US veterans. This study found that among older veterans, a PTSD diagnosis conferred a significantly increased risk of developing dementia, with rates higher throughout the follow-up period. This underscores the importance of screening and treatment for those with PTSD.
Spotlight on Hepatitis B: Clinical Trial Landscape in 2025
Explore the Hepatitis B global clinical trial landscape in 2025 with insights into novel therapies, ongoing research for a functional cure, emerging biomarkers, and investment trends from a new report by Novotech